Perturbed pathways mainly target the degradation of several amino acids and fatty acids, metabolism of pyruvate, glycolysis/gluconeogenesis, signaling of adipocytokine, ketone bodies, glycerophospholipids, the PPAR signaling cascade, calcium signaling, GnRH signaling, the MAPK signaling cascade, the mTOR signaling cascade, the VEGF signaling pathway, TLR signaling, the Fc epsilon RI signaling pathway, and several forms of carcinomas, including pancreatic carcinoma, glioma, and prostate cancer. Here, PPARA is linked to Familial prostate cancer.