Next, we examined the differential expression of a list of genes whose protein products are known as drug targets for the treatment of diabetes (11-beta-HSD1, 17-beta-HSD12, 17bHSD11, GFAT1, PTP-1B, and Sirtuin6) reviewed in [47], and their mode of action is detailed in the indicated paper. The gene discussed is HSD17B12; the disease is diabetes mellitus.