Recently, Le et al. demonstrated that impaired Nrf2 signaling under the pressure of oxidative stress in vitiligo melanocytes determines a C-X-C motif chemokine receptor 3 isoform B-C-X-C motif chemokine ligand 10 (CXCR3B-CXCL10)-dependent apoptosis, directly linking oxidative stress to inflammation [41]. Here, NFE2L2 is linked to vitiligo.