NFE2L2 and cancer: Furthermore, ROS have a multifaceted impact on the onset and development of several types of cancer, including melanoma and nonmelanoma skin cancers, due to the impact on p53, kelch-like ECH-associated protein 1, nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) complex, wingless (Wnt)/β-catenin, retinoblastoma transcriptional corepressor 1 (RB1), and mitogen-activated protein kinase (MAPK) pathways [27].