BAX and vitiligo: An interesting link between apoptosis and impaired mitochondrial dynamics in vitiligo melanocytes emerged in a study proving excessive optic atrophy 1 (OPA1)-dependent inner membrane fusion, loss of normal cristae shape and resultant mitochondrial fragmentation associated with increased Bax expression, cytochrome c release from mitochondria to the cytoplasm, and activation of caspase 9, which ultimately triggers the intrinsic apoptotic program [141].