Senescence has been demonstrated to be part of the degenerative process of vitiligo pathogenesis, as demonstrated by the anomalous expression of a multitude of proteins associated with the senescence-associated secretory phenotype (SASP) including interleukin-6 (IL-6), cyclooxygenase (Cox-2), extracellular matrix metalloproteinases (MMPs), and insulin-like growth factor-binding proteins (IGFBPs) [38]. Here, IL6 is linked to vitiligo.