TM6SF2 and fatty liver disease: Notably, the rs58542926 variant of the Transmembrane 6 superfamily member 2 (TM6SF2) gene, and the variant rs641738 of the Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7) gene, are associated with increased hepatic steatosis and fibrosis, with emerging evidence linking them to renal impairment, possibly through systemic inflammation and lipid dysregulation.