TNFAIP3 and Autoimmunity: Under chronic settings like autoimmunity, STING enforces immunosuppression by constitutively maintaining the expression of key immunoregulatory genes (A20/TNFAIP3, SOCS1, SOCS3, IDO-1), which restrain TLR signaling, limit myeloid hyperactivation, and promote regulatory T cell (Treg) function to prevent pathological inflammation [70].