Thus, a prospective study, using data from a large cohort to evaluate the association between circulating chemerin and the risk of myocardial infarction, stroke, and type 2 diabetes, revealed a strong positive association between chemerin and cardiovascular events, independent of established risk factors, hence suggesting a potential role of chemerin in the development of cardiovascular disease [39]. This evidence concerns the gene RARRES2 and type 2 diabetes mellitus.