In accordance with the seminal effects of astroglial and microglial activation on fibromyalgia pain, we found that both EA or Trpv1 gene deletion concomitantly attenuated behavioral pain responses and both astrocyte and microglia activation in the DRG, SC, hypothalamus, and PAG of a fibromyalgia mice model. The gene discussed is TRPV1; the disease is fibromyalgia.