Both the GFAP and Iba1 expression levels were elevated in the PAG of fibromyalgia model mice (Figure 8A,B, * p < 0.05, n = 6), but in contrast to the DRG, these responses were depleted by both acupoint and the ICV injection of AEA (i.e., both acupoint and ICV injection recapitulated the effects of EA). This evidence concerns the gene AIF1 and fibromyalgia.