TRPV1 and fibromyalgia: The von Frey test demonstrated that ICS induced fibromyalgia-like mechanical hyperalgesia and that this effect was associated with the downregulation of CB1 receptors in the DRG, SC, hypothalamus, and PAG, while the mitigation of hyperalgesia via EA and Trpv1 knockout was associated with the reversal of CB1 receptor downregulation.