A different research study found that rutin successfully mitigates hepatic steatosis by reducing the expression of liver fat synthesis genes (Srebp-1c, Fasn, Scd1) and increasing the expression of genes that promote fat breakdown (Hsl, Atgl, Lpl) and oxidation (Pgc-1α, Cpt-1β, PPAR-α) [43]. The gene discussed is PNPLA2; the disease is fatty liver disease.