AKR7A3 and AL amyloidosis: Similarly, the expression of aldo-keto reductase family 7 member A3 (AKR7A3), an enzyme that detoxifies aldehydes and ketones and has been implicated in cancer-related metabolic and signaling pathways [31,32,33,34,35], was also reduced, indicating that AKR7A3 may contribute to the tumor-promoting effects of UNC13B in multiple myeloma.