PRDM16 and obesity due to melanocortin 4 receptor deficiency: Under specific stimuli, white adipocytes can undergo a phenotypic transition known as “browning,” which is characterized by the upregulation of thermogenic genes including peroxisome proliferator-activated receptor alpha (PPARα), PPARγ coactivator 1-alpha (PGC1α), PR domain-containing 16 (PRDM16), and UCP1, offering a potential mechanism to increase energy expenditure and combat obesity [25,26].