In HIV/TB co-infection, combining miR-223-5p and miR-10 b-5p, which regulate Mtb growth and pro-inflammatory cytokines (e.g., IL-6, IL-8), achieved AUC = 0.96 (sensitivity 86.7%, specificity 91.7%), providing a specific co-infection marker [48]. This evidence concerns the gene CXCL8 and coinfection.