SLC39A8 and acute respiratory distress syndrome: ZIP8 (or SLC39A8) is a divalent metal ion importer expressed in lung, induced under inflammatory conditions that if absent leads to elevated splenic iron levels and hypoferremia; interestingly, ZIP8−/− mice do not develop acute lung injury (ALI) during markedly reduced serum iron, suggesting that this receptor is involved in iron recycling [239].