Hepatocyte surface proteins including hereditary hemochromatosis protein (HFE), hemojuvelin (HJV), transferrin receptor (TFR)2, BMP receptors (ALK2, ALK3, BMPR-II), neogenin, and transmembrane protease serine 6 (TMPRSS6), modulate hepcidin expression in response to BMPs and diferric TF [30]. This evidence concerns the gene TMPRSS6 and hemochromatosis type 1.