After 8 weeks,Glycaemic changes:both an LCD and an HCLF diet significantly (p < 0.01) improved fasting insulin, HOMA IR, rQUICKI, and leptin/adiponectin ratio (p < 0.05) levels.LCD group showed upregulation in lipid metabolites, indicating increased lipid transport and oxidation.−78 metabolites were differentially regulated between groups.Both diets may reduce T2D risk. This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.