RASSF4 and Miyoshi myopathy: Studies have shown that while no significant enrichment of repressive histone modifications (H3K9me3 and H3K27me3) was observed in XG-7 (IL-6-dependent cell line) and MM1S cells, treatment with the histone deacetylase inhibitor (HDACi) quisinostat significantly upregulates RASSF4 protein expression in human MM cell lines (AMO-1 and JJN3) [16], suggesting that a low acetylation state in the RASSF4 promoter region may inhibit its transcription.