Thus, the potential mechanism by which RASSF4 regulates the progression of liver cancer is that RASSF4 reduces transforming growth factor beta (TGF-β) secretion in hepatocytes, which inhibits the activation of hepatic stellate cells (HSCs) and then blocks abnormal proliferation of myofibroblasts and collagen deposition, thereby alleviating the progression of MASH to HCC [27]. Here, RASSF4 is linked to liver cancer.