RASSF4 and lung adenocarcinoma: Additionally, the significant negative correlation between miR-626 and other miRNAs and RASSF4 expression in oral squamous cell carcinoma provides auxiliary diagnostic value [28]; at the tissue expression level, low RASSF4 protein expression in NSCLC is an independent prognostic marker in 41.57% of cases of lung adenocarcinoma and can be used for supplementary typing via immunohistochemistry [44].