RASSF4 and neoplasm: Given the documented roles of promoter hypermethylation and miRNA-mediated downregulation in RASSF4 silencing, promising strategies may involve: (1) epigenetic reactivation; (2) miRNA-mediated regulation of RASSF4 and therapeutic prospects; (3) direct genetic intervention via viral or non-viral vectors to deliver and restore RASSF4 gene expression; (4) combining pathway-specific drugs to enhance RASSF4-mediated tumor suppression (as shown in Figure 6).