Nevertheless, it should be noted that the triggering of autoimmunity differs between subjects exposed to SARS-CoV-2 without prior vaccination and those who have been vaccinated: indeed, subjects exposed to spike proteins by vaccination probably avoid the overcoming of an infective threshold (in terms of viral load) beyond which autoimmunity phenomena may become manifested with clinical signs and symptoms [54]. The gene discussed is CHMP5; the disease is Autoimmunity.