ERN1 and glioblastoma: Sushma et al. reported that 0.5–4% ethanol concentrations caused a significant decrease in cell viability at 48 h of exposure period, induced significant upregulation of pro-apoptotic marker proteins and ER stress sensor proteins (e.g., IRE1, eIF2α, and CHOP), and the downregulation of Bip protein in U-87 (Human glioblastoma) and HMC-3 (Human microglia) cell lines [24].