This is consistent with a strong cooccurrence of neurodevelopmental and neurodegenerative conditions that has been observed in other disease-related conditions such as, for example, in the well-characterized neurodevelopmental roles of the β-amyloid precursor protein (APP) associated with the formation of β-amyloid plaques and Alzheimer’s disease [139,165]. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.