Our results are also similar to studies in NSCLC cells, which reported activation of bombesin receptors [41] resulted in transactivation of the HER3, causing activation of both the MAPK and PI3K/AKT signaling cascades; however, only activation of the MAPK-dependent mechanism was important in mediating cell growth. The gene discussed is ERBB3; the disease is non-small cell lung carcinoma.