EGFR and neoplasm: In NSCLC cells the ErbB family plays these pivotal roles by ligand activation, due to the release of cognate ligands, often due to their transactivation by GPCRs, resulting in stimulation of a number of potent tumor growth cascades (i.e., MAPK, PI3K/AKT, STAT, mTor, RAS, and RAF cascades) [1,29,72].