TTK and familial pancreatic carcinoma: Dong et al. [77] revealed that the expression of histone H3K18la (H3 K18 site lactylation) is significantly elevated in pancreatic cancer following lactate accumulation, which promotes the transcription of its downstream genes threonine tyrosine kinase (TTK) and BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B).