AKT1 and cancer: Key signaling pathways that changed by gene expressions in the presence of 2S-13 in the MDA-MB-231 cell line are pathways in cancer, the PI3K-Akt signaling pathway, the MAPK signaling pathway, the hypoxia-inducible factor 1 (HIF-1) pathway, the p53 signaling pathway, the apoptotic pathway and the cell cycle pathway.