AKT1 and cancer: Key signaling pathways that changed by gene expressions in the presence of DOX in the 4T1 cell line are the PI3K-Akt signaling pathway, pathways in cancer, the MAPK signaling pathway, the hypoxia-inducible factor 1 (HIF-1) pathway, the cell cycle pathway, apoptosis and the RAP1 signaling pathway (Figure 11).