Our previous studies indicated that 7-Methoxyflavanone (7MF) inhibited LPS-stimulated TLR4/MyD88/MAPK signaling and activated the transcription of Nrf2-mediated antioxidant protein NQO-1, thereby exerting anti-neuroinflammatory effects in BV2 cells [17], considering that ALI represents an excessive inflammatory response in the lungs. This evidence concerns the gene TLR4 and acute respiratory distress syndrome.