NLRP3 and acute respiratory distress syndrome: In this study, further molecular mechanistic studies revealed that 7MF also inhibited the expression of GSDMD, thereby inhibiting GSDMD cleavage to release the N-terminal fragment, blocking GSDMD-N from initiating cellular pyroptosis by forming a pore on the cell membrane [39,40], suggesting that it may ameliorate ALI by inhibiting ROS/Txnip/NLRP3 signaling-mediated pyroptosis.