INS and type 1 diabetes mellitus: In patients with T1DM, Agrawal et al. [27] reported that a three-month supplementation with raw CM (500 mL/day), in addition to standard insulin therapy, significantly reduced the required daily insulin dose (from 41.16 ± 10.32 to 30.0 ± 12.06 units/day) along with improved glycemic control as reflected by decreased HbA1c levels.