In luminal B breast cancers, we discovered a relationship that is paradoxical: high WWOX expression can correlate with worse outcomes, potentially due to overactive oxidative phosphorylation and excessive ROS production, or interference from oncogenic partners such as TRIM67, which promotes metastasis, ECM remodelling, and immune evasion via PI3K/Akt and MAPK pathway activation [95,103,104]. Here, PIK3CG is linked to breast carcinoma.