HSPG2 and cancer: Other relevant pathways in cancer, such as focal adhesion, cytoskeleton regulation, and chemokine signalling (VCL, THBS1-4, FLNA, LAMA2/4/5, HSPG2), might also be influenced indirectly by changes in the WWOX/HIF1A ratio, potentially impacting the overall prognosis of low-grade glioma patients.