Upregulated genes such as ACSS1 (log2fc =0.50), PFKFB2 (log2fc = 0.57), GCK (log2fc =0.59), and PGAM2 (log2fc =0.59) indicate potential metabolic adaptations that may support tumour growth, though their impact is less pronounced compared to the WWOX/HIF1A ratio. The gene discussed is HIF1A; the disease is neoplasm.