Specifically, in basal-like breast cancer, we observed that low WWOX/HIF1A ratios correlate with upregulation of key proliferative pathways—including PI3K-Akt, MAPK, Ras, and ErbB signalling—which collectively drive tumour aggressiveness and rapid growth [126,127,128,129]. The gene discussed is WWOX; the disease is breast carcinoma.