Conversely, in the bad prognosis WWOX/HIF1A ratio, the interaction between WWOX and HIF1A could exacerbate the aggressiveness of gliomas by disrupting normal cellular processes such as cell cycle regulation (MMR, BER, HR) (E2F4, SFN, CUL1, SKP2, TGFB2/3, ESCO2), apoptosis (BAK1, BAX), and DNA replication (DNA2, POLE/2, POLD1/3, PCNA, PRIM2, MCMs, RFC2/3/4). The gene discussed is POLE; the disease is central nervous system cancer.