Oxidative phosphorylation components (NDFs, COXs, TCIRG1, LHPP) and chemical carcinogenesis pathways involving reactive oxygen species (CYP1B1, GSTs, AKT2, IKBKB, MAPK3, MAP2K2) exacerbate DNA damage and promote tumour aggressiveness. Here, TCIRG1 is linked to neoplasm.