Similarly, in LGG, we found that a low WWOX/HIF1A ratio fosters invasive phenotypes through HIF-1α-induced VEGF signalling and overexpression of CXCR chemokine receptors (CXCR3/4/5/6), which collectively drive angiogenesis and tumour dissemination. The gene discussed is CXCR3; the disease is neoplasm.