Like in breast cancer, HIF1 activates in HCC cells key enzymes, which are involved in glucose metabolism and glycolysis [46], like GLUT1 [48], HK2, ENO1, GAPDH, PFKL, PGK1, PFKFB3, LDHA [46], and PDK1. Here, HIF1A is linked to hepatocellular carcinoma.