Immune-related pathways such as TNF signalling (Figure 26) (IDH3B/G, MDH1, ACO2, SDHA, OGDHL) and JAK/STAT3 (PIAS2/3, PTPN2, AKT1/2, MCL1, CISH, AOX1) signalling are enriched in gliomas and play a critical role in their progression [72]. The gene discussed is PIAS2; the disease is glioma.