Oxidative phosphorylation components (NDFs, COXs, TCIRG1, LHPP) and chemical carcinogenesis pathways involving reactive oxygen species (CYP1B1, GSTs, AKT2, IKBKB, MAPK3, MAP2K2) exacerbate DNA damage and promote tumour aggressiveness. The gene discussed is LHPP; the disease is neoplasm.