In case of HCC, we demonstrated that favourable HCC cases are characterized by high WWOX/HIF1A ratios that support oxidative metabolism and detoxification (Figure 28), including a 2.5-fold upregulation of CYP3A4 [106] and induction of metallothionein genes such as MT1G, MT1H, MT1F, MT1B, and MT1E [107], which are crucial for antioxidant activity and metal homeostasis, in HCC [107,108,109]. This evidence concerns the gene HIF1A and hepatocellular carcinoma.