What is more, GBM patients harbour a mutation in the genes directly involved in glycolysis as HK2 and GPI, LDHA, LDHB, and LDHD, in addition to mutations in genes responsible for metabolic regulation, such as TP53, HIF1A, STAT3, MTOR [50], which most likely influence the GBM prognosis. This evidence concerns the gene HIF1A and glioblastoma.