In basal-like breast cancer (Figure 27), we found that a low WWOX/HIF1A ratio is associated with particularly aggressive disease because it promotes EMT via ZEB1 and ADAM9, facilitates ECM remodelling via MMP2 and ITGA1, and enables immune evasion via NOTCH1 and TLR4. This evidence concerns the gene TLR4 and breast carcinoma.