E2F4 and central nervous system cancer: Conversely, in the bad prognosis WWOX/HIF1A ratio, the interaction between WWOX and HIF1A could exacerbate the aggressiveness of gliomas by disrupting normal cellular processes such as cell cycle regulation (MMR, BER, HR) (E2F4, SFN, CUL1, SKP2, TGFB2/3, ESCO2), apoptosis (BAK1, BAX), and DNA replication (DNA2, POLE/2, POLD1/3, PCNA, PRIM2, MCMs, RFC2/3/4).