It was found that in breast cancer, the WWOX/HIF1A ratio allows for the identification of groups of patients with favourable and unfavourable prognosis—in basal and HER2 breast cancer subtypes, high WWOX/HIF1A was associated with a more favourable prognosis, whereas in luminal A and B subtypes, it correlated with a less favourable prognosis. This evidence concerns the gene HIF1A and breast cancer.