Conversely, in the bad prognosis WWOX/HIF1A ratio, the interaction between WWOX and HIF1A could exacerbate the aggressiveness of gliomas by disrupting normal cellular processes such as cell cycle regulation (MMR, BER, HR) (E2F4, SFN, CUL1, SKP2, TGFB2/3, ESCO2), apoptosis (BAK1, BAX), and DNA replication (DNA2, POLE/2, POLD1/3, PCNA, PRIM2, MCMs, RFC2/3/4). Here, RFC2 is linked to central nervous system cancer.