In basal-like and HER2-positive breast cancers, we demonstrated that a low WWOX/HIF1A ratio is particularly detrimental, as it triggers HIF1α-mediated upregulation of immunosuppressive mediators such as TLR4, NOTCH1, PTX3, and IL6R, alongside glycolytic enzymes like GLUT1 and HK2 [147,148,149]. The gene discussed is TLR4; the disease is breast cancer.