LHPP and neoplasm: In contrast, HNF4A, RASSF1, SPARCL1, and LHPP are associated with favourable outcomes: HNF4A regulates hepatocyte differentiation [186], RASSF1 acts as a tumour suppressor [187], SPARCL1 inhibits angiogenesis and metastasis [188], and LHPP suppresses tumour growth [143].