Oxidative phosphorylation components (NDFs, COXs, TCIRG1, LHPP) and chemical carcinogenesis pathways involving reactive oxygen species (CYP1B1, GSTs, AKT2, IKBKB, MAPK3, MAP2K2) exacerbate DNA damage and promote tumour aggressiveness. Here, CYP1B1 is linked to neoplasm.