Oxidative phosphorylation components (NDFs, COXs, TCIRG1, LHPP) and chemical carcinogenesis pathways involving reactive oxygen species (CYP1B1, GSTs, AKT2, IKBKB, MAPK3, MAP2K2) exacerbate DNA damage and promote tumour aggressiveness. The gene discussed is AKT2; the disease is neoplasm.