PIK3CA and breast cancer: In luminal B breast cancers, we discovered a relationship that is paradoxical: high WWOX expression can correlate with worse outcomes, potentially due to overactive oxidative phosphorylation and excessive ROS production, or interference from oncogenic partners such as TRIM67, which promotes metastasis, ECM remodelling, and immune evasion via PI3K/Akt and MAPK pathway activation [95,103,104].