Furthermore, pathways involved in xenobiotic metabolism (GSTs, DHDH, AKR7A2, HSD11B1L, CYP1B1, UGTs), drug metabolism, nucleotide metabolism, and homologous recombination (RAD51) reflect the tumour’s ability to adapt to environmental stressors and resist therapy. The gene discussed is AKR7A2; the disease is neoplasm.