IKZF1 and thymus lymphoma: In addition, a high frequency of the interstitial loss-of-heterozygosity pattern at the tumor-suppressor Ikzf1/Ikaros locus on chromosome 11 was reported to occur in murine thymic lymphomas induced by X-rays (1.6 Gy weekly exposure for 4 weeks, with a total dose of 6.4 Gy), as compared with spontaneously developed or alkylating agent–induced lymphomas [11].