Previous studies indicate that Morus alba L. root cortex extract inhibits critical enzymes involved in cholinergic dysfunction (AChE and BChE) and amyloidogenesis (BACE1), reduces malondialdehyde (MDA) levels, attenuates tau pathology, and enhances antioxidant enzyme activity, thus suggesting comprehensive therapeutic benefits for AD. The gene discussed is MAPT; the disease is Alzheimer disease.