On the unified TCGA-GBM/LGG and Erasmus Glioma Database (EGD) test cohort, MGMT-Net achieved AUC scores of 0.94 (IDH), 0.91 (1p/19q), and 0.90 (TERT), outperforming the best baseline model, which reached 0.92, 0.89, and 0.86, respectively. Here, MGMT is linked to glioblastoma.