Recommendations for women with pregestational diabetes include adherence to a diabetes-specific dietary regimen, regular exercise, daily capillary glucose measurements, insulin treatment or antidiabetic medication in refractory cases (i.e., maternal MODY and PCOS), avoidance of excessive weight gain during pregnancy, antioxidant supplementation (folic acid, Mg, Fe, Ca and vitamin D in cases of deficiency) and regular ultrasonographic evaluation of the femoral/omphalic artery as per guidelines [104,105]. The gene discussed is INS; the disease is polycystic ovary syndrome.