Tumor-associated macrophages (TAMs) are prominent components of the TIME, and their polarization state (M1 or M2) determines their function: M1 Macrophages are classically activated macrophages that are induced by stimuli such as lipopolysaccharides (LPS) and interferon-gamma (IFN-γ), and are characterized by the production of pro-inflammatory cytokines and promotion of Th1 responses [34]. The gene discussed is IFNG; the disease is neoplasm.