Particularly, the genetic basis for VMCMs and 40% of sporadic venous malformation is attributable to a mutation in the TEK gene (chromosome 9p), which binds angiopoietins and regulates angiogenesis, cell proliferation, migration, adhesion, and vascular quiescence via the TIE2-PI3K-AKT-mTOR pathway leading to disorganization of periendothelial cells and aberrant angiogenesis. Here, TEK is linked to Venous malformation.