RUNX3 and atopic asthma: In inner-city children with persistent atopic asthma, epigenome-wide profiling revealed 81 differentially methylated regions, 73 hypomethylated and 8 hypermethylated, adjacent to key T-lymphocyte and TH2-immunity genes (IL13, runt-related transcription factor 3 (RUNX3), TIGIT), even after adjusting for age, sex, race/ethnicity, and batch effects.