The endometriosis cycle also showed a significantly lower progesterone-to-estradiol ratio compared to the 28andMe (typical) cycle (P = 0.002), and the OC showed lower progesterone-to-estradiol ratios compared to both the typical cycle (P = 0.045) and the 28andMe (typical) cycle (P < 0.001). The gene discussed is BGLAP; the disease is endometriosis.