Kaplan-Meier survival analysis based on the TCGA-CRC cohort (Fig. 11A-J) revealed that among the 9 Hub genes, high expression of FGF1 (p = 0.037, HR = 1.6) and VEGFC (p = 0.027, HR = 1.6) was significantly associated with poor prognosis in colorectal cancer patients (p < 0.05). This evidence concerns the gene VEGFC and colorectal carcinoma.