CD8A and colorectal carcinoma: The analysis revealed that the most prominently distinct immune cell populations between CRC and mCRC tissues predominantly included APC co-inhibition, CD8+ T cells, checkpoint molecules, cytolytic activity markers, inflammation-promoting factors, MHC class I molecules, T cell co-inhibition markers, T cell co-stimulation factors, T follicular helper (Tfh) cells, and T helper 1 (Th1) cells.