BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; PAC, plasma aldosterone concentration; DRC, direct renin concentration; ARR, plasma aldosterone-to-renin ratio; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; PA, primary aldosteronism; HCs, healthy controls. This evidence concerns the gene REN and primary aldosteronism.