Of note, after orthotopic injection, murine scRNA-seq data revealed GAL4 and HMGA2 to be expressed at relatively distinct poles corresponding to classical and basal/mesenchymal tumor cell clusters, respectively, while GATA6 and VIM were more broadly expressed (Supplementary Fig. 17b), supporting the usefulness of GAL4/HMGA2 specifically to call murine PDAC phenotypes in vivo. This evidence concerns the gene GATA6 and neoplasm.