Hence, to study compartment-related tumor cell phenotypes, we used multiplex IHC with a panel of six markers, two classical (caudal type homeobox 2 [CDX2], mucin 5AC oligomeric mucus/gel forming [MUC5AC]), and four basal markers (Keratin [KRT]5, high mobility group AT-hook 2 [HMGA2], Carbohydrate antigen [CA]125/MUC16, and KRT17; Fig. 2a) in a subcohort of n = 31 patients, for which extensive IHC was available and lobular invasion was present at different degrees (clinical characteristics in Table 1, flow chart of sample analysis in Supplementary Fig. 1). Here, MUC16 is linked to neoplasm.