Based on NGFR/CD146 expression and cellular morphology, the model was trained to recognize acinar cells, exocrine cells undergoing ADM (i.e., cells in an acinar tissue context that had changed morphological appearance toward a more ductal phenotype), ductal cells, immune infiltrates, fibroblasts and ECM (combined to a “fibrosis” class), vessels, nerves, endocrine islets of Langerhans, and tumor cells (Fig. 3a and Supplementary Fig. 11a). This evidence concerns the gene NGFR and neoplasm.