Infection with HTLV-1A/CoI-L resulted in low overall frequency of monocytes, DCs, and neutrophils producing IL-10, with elevated frequencies of those producing TNF-α in both compartments, linked to high expression of IL-6, CCL2, and IL-33 in blood and of MMP1, IL-1β, CCL3, and CCL19 in the lung. Here, CCL3 is linked to infection.