Amongst the most significant synthetic lethal hits are genes that constitute the FANCM complex (FANCM, FAAP24/C19orf40, APITD1/MHF1/CENPS, and STRA13/MHF2/CENPX), the Fanconi Anaemia (FA) core complex (FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FAAP20) and downstream effectors of the FA pathway, including FANCD2 (Fig. 1i, j). The gene discussed is FANCF; the disease is Friedreich ataxia.