Amongst the most significant synthetic lethal hits are genes that constitute the FANCM complex (FANCM, FAAP24/C19orf40, APITD1/MHF1/CENPS, and STRA13/MHF2/CENPX), the Fanconi Anaemia (FA) core complex (FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FAAP20) and downstream effectors of the FA pathway, including FANCD2 (Fig. 1i, j). Here, CENPX is linked to Friedreich ataxia.