Like BRCA1, BRCA1-A complex factors are tumour suppressor genes39, with homozygous deletions in the genes forming the complex estimated at a frequency of 1.04% across all cancer types within the current TCGA cohort of 10,953 patients, and with an additional 1.69% of all cancers harbouring mutations (Table 1). This evidence concerns the gene BRCA1 and neoplasm.