Further analysis revealed three distinct synthetic lethal categories with EXO1 loss: (1) genes previously shown to be synthetic lethal with EXO1 in model organisms or human cells, (2) DDR genes not previously linked to EXO1 loss that are frequently mutated in cancers, and (3) genes frequently mutated in cancer that have not been implicated in genome stability maintenance processes (Fig. 1h–j). The gene discussed is EXO1; the disease is cancer.