For follicular helper T-cells (Tfh), S01 had high expression of T-cell activation genes implicated in anti-tumor immunity including PI4K2B37 as well as the ganglioside checkpoint gene ST8SIA138, S02 had increased CTLA-4 expression, and S03 had increased expression of PD-1 and some overlap with exhausted cluster 13 (TNFRSF18, DUSP4) (Fig. 4b). The gene discussed is TNFRSF18; the disease is neoplasm.