Given the complexity of AD mechanisms, which involve various dysregulated pathways, including tau-mediated neurodegeneration, Aβ-pathway-driven neuroinflammation, synaptic signaling, immune activity, mitochondrial dysfunction, and demyelination [10], omics-based investigations of molecular and cellular pathway disruptions are essential for a better understanding of AD pathogenesis. The gene discussed is MAPT; the disease is Alzheimer disease.