While Cav3.1 (CACNA1G) gain-of-function mutations have been associated with cerebellar ataxia and epilepsy (Weiss and Zamponi, 2020), a recent study highlighted atypical parkinsonism as an additional clinical feature of a CACNA1G channelopathy (Martínez-Villota et al., 2023). This evidence concerns the gene CACNA1G and aceruloplasminemia.