IGHE and Alzheimer disease: The skin of AD patients is often colonized with S. aureus strains that produce superantigens, most commonly staphylococcal enterotoxin B (SEB).27–29 Skin colonization with S. aureus aggravates AD30–36 and is associated with higher concentrations of IgE antibodies to food antigens.37–40 There is a positive association between S. aureus skin colonization and food allergy in AD, independent of disease severity.37,41 Whether this is simply due to higher concentrations of IgE antibodies to food antigens and/or to non-antigen-specific enhancement of food allergy by S. aureus products is unknown.