SEB is the superantigen most commonly produced by S. aureus strains, including COL, that colonize the skin of patients with AD.27 Epicutaneous sensitization of female BALB/c mice with OVA in the presence of purified SEB, hereafter referred to as OVA + SEB, resulted in exaggerated anaphylaxis following oral OVA challenge compared with epicutaneous sensitization with OVA (Figures 2A and 2B). Here, SETBP1 is linked to Alzheimer disease.