The cTfh and T peripheral helper (Tph) subsets lacked a significant difference in the same analysis (Fig. 2D) Furthermore, in late COVID-19, the atypical, CD45RBlo atypical activated (CD45RBlo atypical act) and CD45RB+ activated B cell subsets that we previously identified (23), had a strong positive correlation with several anti-cytokine autoantibodies (IL-6, IL-10, IL-22, and IFN-γ) as well as Tph cells but a negative correlation with Treg subsets including preTfr (Fig. 2B). The gene discussed is IL22; the disease is COVID-19.