In the OF group, our data underlined the reduced transcriptional expression of genes including ADAMDEC1, CPA3, IGFBP1, IGFBP2, SCARA5 and TFAP2C involved in proliferative and metabolic processes, such as “Female genital neoplasm”, “Tumorigenesis of reproductive tract”, “Ovarian tumor”, “Benign solid tumor”. The gene discussed is IGFBP2; the disease is ovarian neoplasm.