FOXM1 and obstructive sleep apnea syndrome: However, the mouse myocardium exhibited decreased FOXM1 expression and increased apoptosis after 12 weeks of CIH exposure, suggesting that the early compensatory protective mechanism was overwhelmed by myocardial injury caused by prolonged hypoxia, leading to enhanced cardiomyocyte apoptosis and consequent FOXM1 downregulation in late-stage OSA.