Out of the 759 mRNAs classified by RNA-seq as differentially expressed between Ctrl-exo- and OSA-exo-treated AC16 cardiomyocytes, 14 mRNAs related to myocardial functions, including PLXDC2, MSANTD1, ISY1-RAB43, TMEM64, NAP1L2, PTK6, FOXM1, RMST, STRA6, NPY1R, CCDC83, CHGA, IKZF1, and GJA5, were selected for verification by RT-qPCR. The gene discussed is TMEM64; the disease is obstructive sleep apnea syndrome.