When evaluating the genotype frequency in the subgroups of cases according to the liver cirrhosis aetiology, the frequency of PNPLA3 G allele was significantly higher in the subgroups with ALD, MASLD and VIR cirrhosis (392 of 577, 67.9%; 133 of 208, 63.9% and 139 of 264, 52,7% p < 0.0001 for all ALD and MET and p = 0.0005 for VIR) than in controls (1448 of 3483; 41.6%). Here, PNPLA3 is linked to Cirrhosis.