The frequency of SERPINA1 MZ heterozygotes was significantly higher in the subgroups with ALD and MASLD (37/557; 6.4% and 23/208; 11.1%, respectively, p < 0.0001); the frequency in the subgroups VIR, AIH-CHOL and MET did not differ from controls. Here, SERPINA1 is linked to autoimmune hepatitis.