SERPINA1 and cirrhosis of liver: When evaluating the genotype frequency in the subgroups of cases according to the liver cirrhosis aetiology, the frequency of SERPINA1 MZ genotype carriers was significantly higher in the subgroups of cases with ALD and MASLD cirrhosis (37 of 577; 6.4% and 23 of 208; 11.1%, respectively, p < 0.0001 for both groups) than in controls (89 of 3402; 2.6%).