MATN3 and cancer: Fig 4B presents a more detailed view of MATN3 mutations and amplifications across various cancers, utilizing data from the cBioPortal. The scatter plot in Fig 4C maps specific mutations within the MATN3 protein, highlighting the types of mutations and their locations within the protein structure. This visualization underscores the critical regions of the MATN3 protein that are frequently targeted by mutations, such as the von Willebrand factor A (vWFA) domains, which are crucial for protein-protein interactions [40].