Furthermore, using GWAS summary statistics from a skin cancer meta-analysis across the FinnGen, Million Veterans Program, and UK Biobank (FinnGen + MVP + UKBB) biobanks (MVP–FinnGen–UKBB Meta-Analysis 2024) as an outcome, we also detected a proportional effect of these 2 missense variants on reducing skin cancer risk (beta = −0.192; Supplementary Fig. 6), mirroring the common HAL eQTL variant associations discussed above (Fig. 3c). The gene discussed is HAL; the disease is skin neoplasm.