Figure 3 shows the course of MAB ATCC 19977infection in the lungs, spleens, and livers of multiple mouse strains (describedin Table 1), including immunocompetentmice (BALB/c and C57BL/6), mice lacking function in the cystic fibrosistransmembrane conductance regulator (CFTR) or nitric oxide synthase 2(NOS-2-KO), mice developing lysosomal storage disease (NPC1 and Hurler) orconnective tissue disorders (Marfan1), diabetes-prone mice lacking C5 of thecomplement system (NOD), or mice lacking T and B cells in the NOD background(NOD-RAG and NOD-SCID). The gene discussed is NOS2; the disease is diabetes mellitus.