NPC1 and Marfan syndrome: The rationale to test these mouse strains was based onreports documenting reduced nitric oxide concentration in the airways of CFpatients (12, 13), phenotypic similarities between patients with Marfansyndrome and those developing non-tuberculous mycobacterium (NTM) infections(14, 15), and manipulation of lysosomal function by pathogenicmycobacteria, particularly NPC1 (16),respectively.