Supervised endotyping utilizes conceptual biological pathways or biomarkers to categorize CRS, often classifying based on single representative cytokines or histologic indicators and binary comparisons (e.g., T2 vs. non‐T2): with conceptual inflammation types Type 1 (T1) characterized by IFN‐γ, Type 2 (T2) characterized by IL‐4, IL‐5, and IL‐13, and Type 3 (T3) characterized by IL‐17 [2, 3, 4]. Here, IL17A is linked to congenital rubella syndrome.