Of note here is the fact that hyperglycemia, ROS, and Aβ trigger the NLRP3 inflammasome to engage caspase-1-dependent synaptotoxic IL-1β release as well as pyroptosis, thus linking metabolic inflammation to neurodegeneration in AD and other neurodegenerative diseases (Wu et al. 2020). The gene discussed is IL1B; the disease is Alzheimer disease.