Insulin resistance also causes the disruption of hyperphosphorylation of tau signaling and leads to activation of Glycogen Synthase Kinase-3β (GSK-3β), which causes abnormal phosphorylation of tau protein, forming neurofibrillary tangles, a key pathological hallmark of AD (Hobday and Parmar 2021). The gene discussed is MAPT; the disease is Alzheimer disease.