In fetuses with apparent isolated BP at midtrimester, genetic testing with chromosome microarray (CMA) and fluorescence in situ hybridization (FISH) for ARSE deletion can be offered for CDPX1 diagnosis while exome sequencing may be more informative in cases where there are other features suggestive of a genetic disorder or if family history indicates a possible inherited condition [26]. This evidence concerns the gene ARSL and hereditary disease.