Additionally, the literature reports that AKT can promote acne development through the downstream MDM2/p53 pathway [35] and enhance the activity of the mTORC1 target, thereby promoting the expression of sterol regulatory element-binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptor gamma (PPAR-γ) [36]. The gene discussed is AKT1; the disease is acne.